Between the central nave windows are large rectangular fresco panels depicting scenes from the lives of Our Lady, King David, and the prophet Isaiah. These were executed by one of the friars called Umile da Foligno as well as by Giovanni Odazzi and Giuseppe Passeri. The style of these panels is lively and ebullient.

Above each column, placed over the entablature, is an elliptical tondo containing a fresco of a Franciscan saint. These total twenty-two, and were painted by fra Umile. Unfortunately, he did not label them. The sleepy nun about to drop out of her tondo, with her little dog trying to get onto her lap, is St Margaret of Cortona.